Linkage Analysis of Factors Underlying Insulin Resistance: Strong Heart Family Study
نویسندگان
چکیده
منابع مشابه
Linkage Analysis of Urine Arsenic Species Patterns in the Strong Heart Family Study.
Arsenic toxicokinetics are important for disease risks in exposed populations, but genetic determinants are not fully understood. We examined urine arsenic species patterns measured by HPLC-ICPMS among 2189 Strong Heart Study participants 18 years of age and older with data on ~400 genome-wide microsatellite markers spaced ~10 cM and arsenic speciation (683 participants from Arizona, 684 from O...
متن کاملLinkage analysis of LDL cholesterol in American Indian populations: the Strong Heart Family Study.
Previous studies have demonstrated that low density lipoprotein cholesterol (LDL-C) concentration is influenced by both genes and environment. Although rare genetic variants associated with Mendelian causes of increased LDL-C are known, only one common genetic variant has been identified, the apolipoprotein E gene (APOE). In an attempt to localize quantitative trait loci (QTLs) influencing LDL-...
متن کاملAuthor ' s response to reviews Title : Linkage Study of Fibrinogen Levels : The Strong Heart Family Study
Lyle G. Best ([email protected]) Kari E. North ([email protected]) Xia Li ([email protected]) Vittorio Palmieri ([email protected]) Jason G. Umans ([email protected]) Jean MacCluer ([email protected]) Sandra Laston ([email protected]) Karin Haack ([email protected]) Harald Goring ([email protected]) Laura Almasy ([email protected]) Elisa T. Lee (elisa-lee@ouh...
متن کاملFasting insulin and obesity-related phenotypes are linked to chromosome 2p: the Strong Heart Family Study.
To localize quantitative trait loci for insulin metabolism and obesity, genome scans/linkage analyses were performed on >900 members of 32 extended families participating in phase 3 of the Strong Heart Study, an investigation of the genetic and environmental determinants of cardiovascular disease in American-Indian populations from Arizona, Oklahoma, and North and South Dakota. Linkage analyses...
متن کاملInsulin sensitivity, insulin secretion, and abdominal fat: the Insulin Resistance Atherosclerosis Study (IRAS) Family Study.
The relationship between insulin sensitivity and overall obesity is well established. However, there remains debate as to which of the fat depots, visceral abdominal tissue (VAT) or subcutaneous abdominal tissue (SAT), is of greater importance. Also, the relationship between fat distribution and insulin secretion is largely unknown. We studied SI, acute insulin response (AIR), and disposition i...
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ژورنال
عنوان ژورنال: Obesity Research
سال: 2005
ISSN: 1071-7323
DOI: 10.1038/oby.2005.230